Publications

2017

  • Nagao, A., Ohara, M., Miyauchi, K., Yokobori, S., Yamagishi, A., Watanabe, K. and Suzuki, T.
    Hydroxylation of a conserved tRNA modification establishes non-universal genetic code in echinoderm mitochondria
    Nature Struct Mol Biol., advance online publication (2017) [Pubmed]
  • Chen, M., Asai, S., Narai, S., Nambu, S., Omura, N., Sakaguchi, Y., Suzuki, T., Ikeda-Saito, M., Watanabe, K., Yao, M., Shigi, N. and Tanaka, Y.
    Biochemical and structural characterization of an oxygen-sensitive 2-thiouridine synthesis catalyzed by an iron-sulfur protein TtuA
    Proc. Natl. Acad. Sci. USA., 114, 4954-4959 (2017) [Pubmed]
  • Kawarada, L., Suzuki, T., Ohira, T., Hirata, S., Miyauchi, K. and Suzuki, T.
    ALKBH1 is an RNA dioxygenase responsible for cytoplasmic and mitochondrial tRNA modifications
    Nucleic Acids Res., 45, 7401-7415 (2017) [Pubmed]
  • Sato, A., Suematsu, T., Aihara, K., Kita, K., Suzuki, T., Watanabe, K., Ohtsuki, T. and Watanabe, Y.
    Duplication of Drosophila melanogaster mitochondrial EF-Tu: pre-adaptation to T-arm truncation and exclusion of bulky aminoacyl residues
    Biochem. J., 474, 957-969 (2017) [Pubmed]
  • Martinez, A., Yamashita, S., Nagaike, T., Sakaguchi, Y., Suzuki, T. and Tomita, K.
    Human BCDIN3D Methylates 5'-phosphate of Cytoplasmic Histidine Transfer RNA
    Nucleic Acids Res., 45, 5423-5436 (2017) [Pubmed]
  • Uchida, H., Matsumura, S., Okada, S., Suzuki, T., Minami, T. and Ito, S.
    RNA editing enzyme ADAR2 is required for neuropathic pain after peripheral nerve injury
    FASEB J., 31, 1847-1855 (2017) [Pubmed]
  • Currie, M. A., Brown, G., Wong, A., Ohira, T., Sugiyama, K., Suzuki, T., Yakunin, A. F., and Jia, Z.
    Structural and functional characterization of the TYW3/Taw3 class of SAM-dependent methyltransferases
    RNA, 23, 346-354 (2017) [Pubmed]
  • Kang, B.+, Miyauchi, K.+, Matuszewski, M., D’Almeida, G. S., Rubio, M., Alfonzo, J. D., Inoue, K., Sakaguchi, Y., Suzuki, T., Sochacka, E. and Suzuki, T.
    Identification of 2-methylthio cyclic N6-threonylcarbamoyladenosine (ms2ct6A) as a novel RNA modification at position 37 of tRNAs
    Nucleic Acids Res., 45, 2124-2136 (2017) [Pubmed] + equal contribution
  • Matuszewski, M., Wojciechowski, J., Miyauchi, K., Gdaniec, Z., Wolf, W. M., Suzuki, T. and Sochacka, E.
    A hydantoin isoform of cyclic N6-threonylcarbamoyladenosine (ct6A) is present in tRNAs
    Nucleic Acids Res., 45, 2137-2149 (2017) [Pubmed]

2016

  • Wu, Y., Wei, F-Y, Kawarada, L., Suzuki, T., Araki, K., Fujimura, A., Kaitsuka, T., Oike, Y., Suzuki, T., and Tomizawa, K.
    Mtu1-mediated thiouridine formation of mitochondrial tRNAs is required for mitochondrial translation and is involved in reversible infantile liver
    PLOS Genet., 12(9), e1006355 (2016) [Pubmed]
  • Bar-Yaacov, D., Frumkin, I., Yashiro, Y., Chujo, T., Ishigami, Y., Chemla, Y., Blumberg, A., Schlesinger, O., Bieri, P., Greber, B., Ban, N., Zarivach, R., Alfonta, L., Pilpel, Y., Suzuki, T. and Mishmar, D.
    Mitochondrial 16S rRNA is methylated by tRNA methyltransferase TRMT61B in all vertebrates
    PLOS Biol., 14(9), e1002557 (2016) [Pubmed]
  • Ohira, T. and Suzuki, T.
    Precursors of tRNAs are stabilized by methylguanosine cap structures
    Nature Chem Biol., 12, 648-655 (2016) [Pubmed]
  • Nakano, S.+, Suzuki, T.+, Kawarada, L., Iwata, H., Asano, K. and Suzuki, T.
    NSUN3 methylase initiates 5-formylcytidine biogenesis in human mitochondrial tRNAMet
    Nature Chem Biol., 12, 546-551 (2016) [Pubmed] + equal contribution
  • Frye, M., Jaffrey, S., Pan, T., Rechavi, G. and Suzuki, T.
    RNA modifications: what have we learned and where are we headed?
    Nature Rev Genet., 17, 365-372 (2016) [Pubmed]
  • Izumi, N., Shoji, K., Sakaguchi, Y., Honda, S., Kirino, Y., Suzuki, T., Katsuma, S. and Tomari, Y.
    Identification and Functional Analysis of the Pre-piRNA 3' Trimmer in Silkworms
    Cell, 164, 962-973 (2016) [Pubmed]
  • Sakai, Y., Miyauchi, K., Kimura, S., & Suzuki, T.
    Biogenesis and growth phase-dependent alteration of 5-methoxycarbonylmethoxyuridine in tRNA anticodons
    Nucleic Acids Res., 44, 509-523 (2016) [Pubmed]
  • Kohda, M., Tokuzawa, Y., Kishita, Y., Moriyama, Y., Mizuno, Y., Hirata, T., Yatsuka, Y., Yamashita-Sugahara, Y., Nakachi, Y., Kato, H., Okuda, A., Tamaru, S., Nyuzuki, H., Borna, N. N., Banshoya, K., Aigaki, T., Sato-Miyata, Y., Ohnuma, K., Suzuki, T., Nagao, A., Maehata, H., Matsuda, F., Higasa, K., Nagasaki, M., Yasuda, J., Yamamoto, M., Harashima, H., Yamazaki, H., Mori, M., Murayama, K., Ohtake, A. and Okazaki, Y.
    A comprehensive genomic analysis reveals the genetic landscape of mitochondrial respiratory chain complex deficiencies
    PLOS Genet., 12(1), e1005679 (2016) [Pubmed]

2015

  • Arai, T., Ishiguro, K., Kimura, S., Sakaguchi, Y., Suzuki, T. and Suzuki, T.
    A single methylation of 23S rRNA triggers late steps of 50S ribosomal
    subunit assembly
    Proc. Natl. Acad. Sci. USA., 112, E4707-E4716 (2015) [Pubmed]
  • Katoh, T., Hojo, H. and Suzuki, T.
    Destabilization of microRNA-122 in human cells by 3' deadenylation mediated
    by PARN and CUGBP1
    Nucleic Acids Res., 43, 7521-7534 (2015) [Pubmed]
  • Shoji, T., Takaya, A., Sato, Y., Kimura, S., Suzuki, T. and Yamamoto, T.
    RlmCD-mediated U747 methylation promotes efficient G748 methylation by
    methyltransferase RlmAII in 23S rRNA in Streptococcus pneumoniae; interplay
    between two rRNA methylations responsible for telithromycin susceptibility
    Nucleic Acids Res., 43, 8964-8972 (2015) [Pubmed]
  • Kyuma, T., Kimura, S., Hanada, Y., Suzuki, T., Sekimizu, K. and Kaito, C.
    Ribosomal RNA methyltransferases contribute to Staphylococcus aureus virulence
    FEBS J., 282, 2570-2584 (2015) [Pubmed]
  • Sakaguchi, Y., Miyauchi, K., Kang, B. and Suzuki, T.
    Nucleoside analysis by hydrophilic interaction liquid chromatography coupled with mass spectrometry
    Methods in Enzymol., 560, 19-28 (2015) [Pubmed]
  • Okada, S., Sakurai, M., Ueda, H. and Suzuki, T.
    Biochemical and transcriptome-wide identification of A-to-I RNA editing sites by ICE-seq
    Methods in Enzymol., 10, 715-732 (2015) [Pubmed]
  • Iwasaki, S., Sasaki, H. M., Sakaguchi, Y., Suzuki, T., Tadakuma, H. and Tomari, Y.
    Defining fundamental steps in the assembly of Drosophila RNAi enzyme complex
    Nature, 521, 533-536 (2015) [Pubmed]
  • Wei, F., Zhou, B., Suzuki, T., Miyata, K., Ujihara, Y., Takahashi, N., Xie, P., Michiue, H., Fujimura, A., Kaitsuka, T., Matsui, H., Koga, Y., Mohri, S., Suzuki, T., Oike, Y. and Tomizawa, K.
    Cdk5rap1-mediated 2-methylthio modification of mitochondrial tRNAs governs precise
    mitochondrial protein translation and contributes to myopathy in mice and humans
    Cell Metab., 21, 428-442 (2015) [Pubmed]
  • Suzuki, T., Ueda, H., Okada, S. and Sakurai, M.
    Transcriptome-wide identification of adenosine-to-inosine editing
    using the ICE-seq method
    Nature Protocol, 10, 715-732 (2015) [Pubmed]
  • Yoshida, M., Kataoka, N., Miyauchi, K., Ohe, K., Iida, K., Yoshida, S., Nojima, T., Okuno, Y., Onogi, H., Usui, T., Takeuchi, A., Hosoya, T., Suzuki, T. and Hagiwara, M.
    Rectifier of aberrant mRNA splicing recovers tRNA modification in
    familial dysautonomia
    Proc. Natl. Acad. Sci. USA., 112, 2764-2769 (2015) [Pubmed]
  • Kimura, S. and Suzuki, T.
    Iron-sulfur proteins responsible for RNA modifications
    Biochim Biophys Acta., 1853, 1272-1283 (2015) [Pubmed]
  • Ishida, K., Miyauchi, K., Kimura, Y., Mito, M., Okada, S., Suzuki, T. and Nakagawa, S.
    Regulation of gene expression via retrotransposon insertions and the noncoding RNA 4.5S RNAH
    Genes Cells., 20, 887-901 (2015) [Pubmed]

2014

  • Ito, S., Horikawa, S., Suzuki, T., Kawauchi, H., Tanaka, Y., Suzuki, T. and Suzuki, T.
    Human NAT10 is an ATP-dependent RNA acetyltransferase responsible for
    N4-acetylcytidine formation in 18S rRNA
    J. Biol. Chem. 289, 35724-35730 (2014) [Pubmed]
  • Suzuki, T. and Numata, T.
    Convergent evolution of AUA decoding in bacteria and archaea
    RNA Biol., 11, 1586-1596 (2014) [Pubmed]
  • Takai, H., Masuda, K., Sato, T., Sakaguchi, Y., Suzuki, T., Suzuki, T., Koyama-Nasu, R., Nasu-Nishimura, Y., Katou, Y., Ogawa, H., Morishita, Y., Kozuka-Hata, H., Oyama, M., Todo, T., Ino, Y., Mukasa, A., Saito, N., Toyoshima, C., Shirahige, K. and Akiyama, T.
    5-Hydroxymethylcytosine plays a critical role in glioblastomagenesis by recruiting the CHTOP-methylosome Complex
    Cell Reports 9, 48-60 (2014) [Pubmed]
  • Ito, S., Akamatsu, Y., Noma, A., Kimura, S., Miyauchi, K., Ikeuchi, Y., Suzuki, T. and Suzuki, T.
    A single acetylation of 18S rRNA is essential for biogenesis of the small ribosomal subunit in Saccharomyces cerevisiae
    J. Biol. Chem. 289, 26201-26212 (2014) [Pubmed]
  • Kimura, S., Miyauchi, K., Ikeuchi, Y., Thiaville, P.C., de Crécy-Lagard, V. and Suzuki, T.
    Discovery of the β-barrel–type RNA methyltransferase responsible for N6-methylation of N6-threonylcarbamoyladenosine in tRNAs
    Nucleic Acids Res. 42, 9350-9365 (2014) [Pubmed]
  • Suzuki, T. and Suzuki, T.
    A complete landscape of post-transcriptional modifications in mammalian mitochondrial tRNAs
    Nucleic Acids Res. 42, 7346-7357 (2014) [Pubmed]
  • Bhaskaran, H., Taniguchi, T., Suzuki, T., Suzuki, T. and Perona, J. J.
    Structural dynamics of a mitochondrial tRNA possessing weak thermodynamic stability
    Biochemistry, 53, 1456-1465 (2014) [Pubmed]
  • Sakurai, M., Ueda, H., Yano, T., Okada, S., Terajima, H., Mitsuyama, T., Toyoda, A., Fujiyama, A., Kawabata, H. and Suzuki, T.
    A biochemical landscape of A-to-I RNA editing in the human brain transcriptome
    Genome Res, 24, 522-534 (2014) [Pubmed]
  • Suzuki, T., Miyauchi, K., Sakaguchi, Y. and Suzuki, T.
    Biochemical and mass spectrometric analysis of 3'-end methylation of piRNAs
    Methods in Mol Biol, 1093, 59-72 (2014) [Pubmed]

2013

  • Yoda, M., Cifuentes, D., Izumi, N., Sakaguchi, Y., Suzuki, T., Giraldez, A.J. and Tomari, Y.
    Poly(A)-specific ribonuclease mediates 3'-end trimming of Argonaute2-cleaved precursor microRNAs
    Cell Reports, 14, 715-726 (2013) [Pubmed]
  • Tomikawa, C., Ohira, T., Inoue, Y., Kawamura, T., Yamagishi, A., Suzuki, T. and Hori, H.
    Distinct tRNA modifications in the thermo-acidophilic archaeon, Thermoplasma acidophilum
    FEBS Lett., 587, 3575-3580 (2013) [Pubmed]
  • Xie, P., Wei, F.-Y., Hirata, S., Kaitsuka, T., Suzuki, T., Suzuki, T. and Tomizawa, K.
    Measurement of tRNA 2-methylthio modification by quantitative PCR for assessing type 2 diabetes risk
    Clinical Chemistry, 59, 1604-1612 (2013) [Pubmed]
  • Taniguchi, T., Miyauchi, K., Nakane, D., Miyata, M., Muto, A., Nishimura, S. and Suzuki, T.
    Decoding system for the AUA codon by tRNAIle with the UAU anticodon in Mycoplasma mobile
    Nucleic Acids Res., 41, 2621-2631 (2013) [Pubmed]
  • Miyauchi, K., Kimura, S. and Suzuki, T.
    A cyclic form of N6-threonylcarbamoyladenosine as a widely distributed tRNA hypermodification
    Nature Chem Biol., 9, 105-111 (2013) [Pubmed]
  • Ohira, T., Suzuki, T., Miyauchi, K., Suzuki, T., Yokobori, S., Yamagishi, A. and Watanabe, K.
    Decoding mechanism of non-universal genetic codes in Loligo bleekeri mitochondria
    J. Biol. Chem., 288, 7645-7652 (2013) [Pubmed]
  • Kita, S., Tanaka, Y., Hirano, N., Kimura, S., Suzuki, T., Suzuki, T., Yao, M. and Tanaka, I.
    Crystal structure of a putative methyltransferase SAV1081 from Staphylococcus aureus
    Protein & Peptide Letters, 20, 530-537 (2013) [Pubmed]

2012

  • Chujo, T. and Suzuki, T.
    Trmt61B is a methyltransferase responsible for 1-methyladenosine at position 58 of human mitochondrial tRNAs
    RNA,18, 2269-2276 (2012) [Pubmed]
  • Rodriguez, V., Vasudevan, S., Noma, A., Carlson, B.A., Green, J.E., Suzuki, T. and Chandrasekharappa, SC.
    Structure-function analysis of human TYW2 enzyme required for the biosynthesis of a highly modified wybutosine (yW) base in phenylalanine-tRNA
    PLoS ONE, 7(6):e39297 (2012) [Pubmed]
  • Chujo, T., Ohira, T., Sakaguchi, Y., Goshima, N., Nomura, N., Nagao, A. and Suzuki, T.
    LRPPRC/SLIRP suppresses PNPase-mediated mRNA decay and promotes polyadenylation in human mitochondria
    Nucleic Acids Res., 40, 8033-8047 (2012) [Pubmed]
  • Kimura, S., Ikeuchi, Y., Kitahara, K., Sakaguchi, Y., Suzuki, T. and Suzuki, T.
    Base methylations in the double-stranded RNA by a fused methyltransferase bearing unwinding activity
    Nucleic Acids Res., 40, 4071-4085 (2012) [Pubmed]
  • Higa-Nakamine, S., Suzuki, T., Uechi, T., Chakraborty, A., Nakajima, Y., Nakamura, M., Hirano, N., Suzuki, T. and Kenmochi, N.
    Loss of snoRNA impairs ribosomal RNA modification and causes developmental defects in zebrafish
    Nucleic Acids Res., 40, 391-398 (2012) [Pubmed]

2011

  • Yu, F., Tanaka, Y., Yamashita, K., Suzuki, T., Nakamura, A., Hirano, N., Suzuki, T., Yao, M. and Tanaka, I.
    Molecular basis of dihydrouridine formation on tRNA
    Proc. Natl. Acad. Sci. USA., 108, 19593-19598 (2011) [Pubmed]
  • Osawa, T., Inanaga, H., Kimura, S., Terasaka, N., Suzuki, T. and Numata, T.
    Crystallization and preliminary X-ray diffraction analysis of an archaeal tRNA modification enzyme TiaS complexed with tRNAIle2 and ATP
    Acta Crystallograph Sect F Struct Biol Cryst Commun., 67, 1414-1416 (2011) [Pubmed]
  • Osawa, T., Terasaka, N., Kimura, S., Inanaga, H., Suzuki, T. and Numata, T.
    Structural basis of tRNA agmatinylation essential for AUA codon decoding
    Nature Struct Mol Biol., 18, 1275-1280 (2011) [Pubmed]
  • Terasaka, N., Kimura, S., Osawa, T., Numata, T. and Suzuki, T.
    Biogenesis of 2-agmatinylcytidine catalyzed by the dual protein and RNA kinase TiaS
    Nature Struct Mol Biol., 18, 1268-1274 (2011) [Pubmed]
  • Suzuki, T., Miyauchi, K., Suzuki, T., Yokobori, S., Shigi, N., Kondow, A., Takeuchi, N., Yamagishi, A. and Watanabe, K.
    Taurine-containing uridine modifications in tRNA anticodons are required to decipher non-universal genetic codes in ascidian mitochondria
    J. Biol. Chem., 286, 35494-35498 (2011) [Pubmed]
  • Suzuki, T., Nagao, A. and Suzuki, T.
    Human mitochondrial tRNAs: biogenesis, function, structural aspects and diseases
    Annu Rev Genet., 45, 299-329(2011) [Pubmed]
  • Wei, F., Suzuki, T., Watanabe, S., Kimura, S., Kaistuka, T., Fujimura, A., Matsui, H., Atta, M., Fontecave, M., Yamagata, K., Suzuki, T. and Tomizawa, K.
    Deficit of Lys-tRNA Modification by Cdkal1 Causes the Development of Type 2 Diabetes in Mice
    J. Clin. Invest., 121, 3598-608 (2011) [Pubmed]
  • Ohira, T. and Suzuki, T.
    Retrograde nuclear import of tRNA precursors is required for modified base biogenesis in yeast
    Proc. Natl. Acad. Sci. USA., 108, 10502-10507 (2011) [Pubmed]
  • Noma, A., Yi, S., Katoh, T., Takai, Y., Suzuki, T. and Suzuki, T.
    Actin-binding protein ABP140 is a methyltransferase responsible for 3-methylcytidine at position 32 of tRNAs in Saccharomyces cerevisiae
    RNA, 17, 1111-1119 (2011) [Pubmed]
  • Suzuki, T. , Nagao, A. and Suzuki, T.
    Human mitochondrial diseases caused by lack of taurine-modification in mitochondrial tRNAs
    WIREs RNA., 2, 376-386 (2011) [Pubmed]
  • Bonneford, L., Arai, T., Sakaguchi, Y., Suzuki, T., Ishitani, R. and Nureki, O.
    Structural basis for nonribosomal peptide synthesis by an aminoacyl-tRNA synthetase paralog
    Proc. Natl. Acad. Sci. USA., 108, 3912-3917 (2011) [Pubmed]
  • Kato, M., Araiso, Y., Noma, A., Nagao, A., Suzuki, T., Ishitani, R. and Nureki, O.
    Crystal structure of a novel jmjC-domain-containing protein, TYW5, involved in tRNA modification
    Nucleic Acids Res., 39, 1576-1585 (2011) [Pubmed]
  • Sakurai, M. and Suzuki, T.
    A biochemical identification of A-to-I RNA editing sites by the Inosine Chemical Erasing (ICE) method
    Methods in Mol Biol, 718, 89-99 (2011) [Pubmed]

2010

  • Sakurai, M., Yano, T., Kawabata, H., Ueda, H. and Suzuki, T.
    Inosine cyanoethylation identifies A-to-I RNA editing sites in the human transcriptome
    Nature Chem Biol., 6, 733-740 (2010) [Pubmed]
  • Ikeuchi, Y., Kimura, S., Numata, T., Nakamura, D., Yokogawa, T., Ogata, T., Wada, T., Suzuki, T. and Suzuki, T.
    Agmatine-conjugated cytidine in a tRNA anticodon is essential for AUA decoding in archaea
    Nature Chem Biol., 6, 277-282 (2010) [Pubmed]
  • Noma, A., Ishitani, R., Kato, M., Nagao, A., Nureki, O. and Suzuki, T.
    Expanding role of the Jumonji C domain as an RNA hydroxylase
    J. Biol. Chem.,285, 34503-34507 (2010) [Pubmed]
  • Zhou, X., Zuo, Z., Zhou, F., Zhao, W., Sakaguchi, Y., Suzuki, T., Suzuki, T., Cheng, H. and Zhou, R.
    Profiling sex-specific piRNAs in Zebrafish
    Genetics, 186, 1175-1185 (2010) [Pubmed]
  • Mimaki, M., Hatakeyama, H., Komaki, H., Yokoyama, M., Arai, H., Kirino, Y., Suzuki, T., Nishino, I., Nonaka, I. and Goto, Y.
    Reversible infantile respiratory chain deficiency: a clinical and molecular study
    Annals of Neurology,68,845-854 (2010) [Pubmed]
  • Iwasaki, S., Kobayashi, M., Yoda, M., Sakaguchi, Y., Suzuki, T. and Tomari, Y.
    Hsc70/Hsp90 chaperone machinery mediates ATP-dependent RISC-loading of small RNA duplexes
    Mol Cell, 39, 292-299 (2010) [Pubmed]
  • Kimura, S. and Suzuki, T.
    Fine-tuning of the ribosomal decoding center by conserved methyl-modifications in the Escherichia coli 16S rRNA
    Nucleic Acids Res., 38, 1341-1352 (2010) [Pubmed]
  • Suzuki, T. and Miyauchi, K.
    Discovery and characterization of tRNAIle lysidine synthetase (TilS)
    FEBS Lett., 584, 272-277 (2010) [Pubmed]

2009

  • Shoji, M., Tanaka, T., Hosokawa, M., Reuter, M., Stark, A., Kato, Y., Kondoh, G., Okawa, K., Chujo, T., Suzuki, T., Hata, K., Martin, S. L.,Noce, T., Kuramochi-Miyagawa, S., Nakano, T., Sasaki, H., Pillai, R. S., and Nakatsuji, N. and Chuma, S.
    The TDRD9-MIWI2 complex is essential for piRNA-mediated retrotransposon silencing in the mouse male germline
    Dev Cell, 17, 775-787 (2009) [Pubmed]
  • Nakanishi, K., Bonnefond, L., Kimura, S., Suzuki, T., Ishitani, R. and Nureki, O.
    Structural basis for translational fidelity ensured by tRNA lysidine synthetase
    Nature, 461, 1144-1148 (2009) [Pubmed]
  • Messmer, M., Putz, J., Suzuki, T., Suzuki, T., Sauter, C., Sissler, M. and Florentz, C.
    Tertiary network in mammalian mitochondrial tRNAAsp revealed by solution probing and phylogeny
    Nucleic Acids Res., 37, 6881-6895 (2009) [Pubmed]
  • Nagao, A., Suzuki, T., Katoh, T., Sakaguchi, Y. and Suzuki, T.
    Biogenesis of glutaminyl-mt tRNAGln in human mitochondria
    Proc. Natl. Acad. Sci. USA., 106, 16209-16214 (2009) [Pubmed]
  • Umitsu, M., Nishimasu, H., Noma, A., Suzuki, T., Ishitani, R. and Nureki, O.
    Structural basis of AdoMet-dependent aminocarboxypropyl transfer reaction catalyzed by tRNA-wybutosine synthesizing enzyme, TYW2
    Proc. Natl. Acad. Sci. USA., 106, 15616-15621 (2009) [Pubmed]
  • Valente, L., Shigi, N., Suzuki, T. and Zeviani, M.
    The R336Q mutation in human mitochondrial EFTu prevents the formation of an active mt-EFTu•GTP•aa-tRNA ternary complex
    Biochim Biophys Acta., 1792, 791-795 (2009) [Pubmed]
  • Awai, T., Kimura, S., Tomikawa, C., Ochi, A., Ihsanawati, I., Bessho, Y., Yokoyama, S., Ohno, S., Nishikawa, K., Yokogawa, T., Suzuki, T., Hori, H.
    Aquifex aeolicus tRNA (N2, N2-guanine)-dimethyltransferase (Trm1) catalyzes transfer of methyl groups not only to guanine 26 but also to guanine 27 in tRNA
    J. Biol. Chem., 284, 20467-20478 (2009) [Pubmed]
  • Kitahara, K. and Suzuki, T.
    The ordered transcription of RNA domains is not essential for ribosome biogenesis
    Mol Cell, 34, 760-766 (2009) [Pubmed]
  • Suzuki, Y., Noma, A., Suzuki, T., Ishitani, R. and Nureki, O.
    Structural basis of tRNA modification with CO2 fixation and methylation by wybutosine synthesizing enzyme TYW4
    Nucleic Acids Res., 37, 2910-2915 (2009) [Pubmed]
  • Chimnaronk, S., Suzuki, T., Manita, T., Ikeuchi, Y., Yao, M., Suzuki, T. and Tanaka, I.
    RNA helicase module in an acetyltransferase that modifies a specific tRNA anticodon
    EMBO J., 28, 1362-1373 (2009) [Pubmed]
  • Ogata, T., Shimazaki, T., Umemoto, T., Kurata, S., Ohtsuki, T., Suzuki, T. and Wada, T.
    Chemical synthesis and properties of 5-taurinomethyluridine and 5-taurinomethyl-2-thiouridine
    J. Org. Chem., 74, 2585-2588 (2009) [Pubmed]
  • Katoh, T., Sakaguchi, Y., Miyauchi, K., Suzuki, T., Kashiwabara, S., Baba, T. and Suzuki, T.
    Selective stabilization of mammalian microRNAs by 3'-adenylation mediated by the cytoplasmic poly(A) polymerase GLD-2
    Genes Dev., 23, 433-438 (2009) [Pubmed]
  • Noma, A., Shigi, N. and Suzuki, T.
    Biogenesis and functions of thio-compounds in transfer RNA: comparison of bacterial and eukaryotic thiolation machineries
    DNA and RNA modification enzymes (Book LANDES), Chapter 27, 392-405 (2009) [about...]
  • Noma, A., Sakaguchi, Y. and Suzuki, T.
    Mechanistic characterization of the sulfur-relay system for eukaryotic 2-thiouridine biogenesis at tRNA wobble positions
    Nucleic Acids Res., 37, 1335-1352 (2009) [Pubmed]

2008

  • Shigi, N., Sakaguchi, Y., Asai, S., Suzuki, T. and Watanabe, K. Common thiolation mechanism in the biosynthesis of tRNA thiouridine and sulphur-containing cofactors
    EMBO J., 27, 3267-3278 (2008) [Pubmed]
  • Ikeuchi, Y., Kitahara, K. and Suzuki, T. The RNA acetyltransferase driven by ATP hydrolysis synthesizes N4-acetylcytidine of tRNA anticodon
    EMBO J., 27, 2194-2203 (2008) [Pubmed]
  • Nagao, A., Shigi-Hino, N. and Suzuki, T. Measuring mRNA decay in human mitochondria
    Methods Enzymol., 447, 489-499 (2008) [Pubmed]
  • Yokoyama, T. and Suzuki, T. Ribosomal RNAs are tolerant toward genetic insertions: Evolutionary origin of the expansion segments
    Nucleic Acids Res., 36, 3539-3551 (2008) [Pubmed]
  • Kurata, S., Weixlbaumer, A., Ohtsuki, T., Shimazaki, T., Wada, T., Kirino, Y., Takai, K., Watanabe, K. Ramakrishnan, V. and Suzuki, T. Modified uridines with C5-methylene substituents at the first position of the tRNA anticodon stabilize U•G wobble pairing during decoding
    J. Biol. Chem., 283, 18801-18811 (2008) [Pubmed]

2007

  • Funakoshi, Y., Doi, Y., Hosoda, N., Uchida, N., Osawa, M., Shimada, I., Tsujimoto, M., Suzuki, T., Katada, T. and Hoshino, S. Mechanism of mRNA deadenylation: evidence for a molecular interplay between translation termination factor eRF3 and mRNA deadenylases
    Genes Dev., 21, 3135-3148 (2007) [Pubmed]
  • Watanabe, K. and Suzuki, T. Universal genetic code and its natural variations
    the Encyclopedia of Life Science, (Macmillan Publishers Ltd), in press (2007)
  • Tsutsumi, S., Sugiura, R., Ma, Y., Tokuoka, H., Ohta, K., Ohte, R., Noma, A., Suzuki, T. and Kuno, T. (2007) Wobble inosine tRNA modification is essential for cell cycle progression in G1/S and G2/M transitions in fission yeast
    J. Biol. Chem., 282, 33459-33465. [Pubmed]
  • Suzuki, Y., Noma, A., Suzuki, T., Senda, M., Senda, T., Ishitani, R. and Nureki, O Crystal structure of the radical SAM enzyme catalyzing tricyclic modified base formation in tRNA
    J. Mol. Biol., 372, 1204-1214 (2007) [Pubmed]
  • Saito, K., Sakaguchi, Y., Suzuki, T., Suzuki, T., Siomi, H. and Siomi, M.C. Pimet, the Drosophila homolog of HEN1, mediates 2'-O-methylation of Piwi-interacting RNAs at their 3' ends
    Genes Dev., 21, 1603-1608 (2007) [Pubmed]
  • Kitahara, K., Kajiura, A., Sato, N.S. and Suzuki, T. Functional genetic selection of Helix 66 in Escherichia coli 23S rRNA identified the eukaryotic class of binding sequences for ribosomal protein L2
    Nucleic Acids Res., 35, 4018-4029 (2007) [Pubmed]
  • Suzuki, T., Sakaguchi, Y. and Suzuki, T. Mass spectrometric analysis of 3'-terminal nucleosides in non-coding RNAs
    Nat Protoc., DOI: 10.1038/nprot.2007.185 (2007) [Epub]
  • Ohara, T., Sakaguchi, Y., Suzuki, T., Ueda, H., Miyauchi, K. and Suzuki, T. The 3' termini of mouse Piwi-interacting RNAs are 2'-O-methylated
    Nat Struct Mol Biol., 14, 349-350 (2007) [Pubmed]
  • Dunham, C.M., Selmer, M., Phelps, S.S., Suzuki, T., Joseph, S. and Ramakrishnan, V. Structures of tRNAs with an expanded anticodon loop in the decoding center of the 30S Ribosomal Subunit
    RNA, 13, 817-823 (2007) [Pubmed]
  • Nakai, Y., Nakai, M., Lill, R., Suzuki, T. and Hayashi, H. Thio modification of yeast cytosolic tRNA is an iron-sulfur protein-dependent pathway
    Mol Cell Biol., 27, 2841-2847 (2007) [Pubmed]
  • Suzuki, T. and Suzuki, T. Chaplet column chromatography: isolation of a large set of individual RNAs in a single step.
    Methods Enzymol., 425, 231-239 (2007) [Pubmed]
  • Suzuki, T., Ikeuchi, Y., Noma, A., Suzuki, T. and Sakaguchi, Y. Mass spectrometric identification and characterization of RNA-modifying enzymes.
    Methods Enzymol., 425, 211-229 (2007) [Pubmed]
  • Miyauchi, K., Ohara, T. and Suzuki, T. Automated parallel isolation of multiple species of non-coding RNAs by the reciprocal circulating chromatography method
    Nucleic Acids Res., 35, e24 (2007) [Pubmed]
  • Katoh, T. and Suzuki, T. Specific residues at every third position of siRNA shape its efficient RNAi activity
    Nucleic Acids Res., 35, e27 (2007) [Pubmed / Epub][siExplorer]

2006

  • Sato, N.S., Hirabayashi, N., Agmon, I., Yonath, A. and Suzuki, T. Comprehensive genetic selection revealed bases essential for protein synthesis in the peptidyl-transferase center.
    Proc. Natl. Acad. Sci. USA., 103, 15386-15391 (2006) [Pubmed]
  • Komoda, T., Sato, N.S., Phelps, S.S., Namba, N., Joseph, S. and Suzuki, T. The A-site finger in 23S rRNA acts as a functional attenuator for translocation
    J. Biol. Chem., 281, 32303-32309 (2006) [Pubmed]
  • Takeda, H., Toyooka, T., Ikeuchi, Y., Yokobori, S., Okadome, K., Takano, F., Oshima, T., Suzuki, T., Endo, Y. and Hori, H. The substrate specificity of tRNA (m1G37) methyltransferase (TrmD) from Aquifex aeolicus.
    Genes Cells, 11, 1353-1365 (2006) [Pubmed]
  • Sato, A., Watanabe, Y., Suzuki, T., Komiyama, M., Watanabe, K. and Ohtsuki, T. Identification of the residues involved in the unique serine specificity of Caenorhabditis elegans mitochondrial EF-Tu2.
    Biochemistry, 45, 10920-10927 (2006) [Pubmed]
  • Numata, T., Ikeuchi, Y., Fukai, S., Suzuki, T. and Nureki, O. Snapshots of tRNA sulfuration via an adenylated intermediate
    Nature, 442, 419-424 (2006) [Pubmed]
  • Guan, M.X., Yan, Q., Li, X., Bykhovskaya, Y., Gallo-Teran, J., Hajek, P., Umeda, N., Zhao, H., Garrido, G., Mengesha, E., Suzuki, T., del Castillo, I., Peters, J. L., Li, R., Qian, Y., Wang, X., Shohat, M., Estivill, X., Watanabe, K. and Fischel-Ghodsian, N. Mutation in TRMU related to mitochondrial tRNA modification modulates the phenotypic expression of the deafness-associated mitochondrial 12S rRNA mutations
    Am J Hum Genet., 79, 291-302 (2006) [Pubmed]
  • Numata, T., Ikeuchi, Y., Fukai, S., Adachi, H., Matsumura, H., Takano, K., Murakami, S., Inoue, T., Mori, Y., Sasaki, T., Suzuki, T. and Nureki, O. Crystallization and preliminary X-ray analysis of the tRNA thiolation enzyme MnmA from Escherichia coli complexed with tRNAGlu.
    Acta Crystallograph Sect F Struct Biol Cryst Commun., 62, 368-371 (2006) [Pubmed]
  • Hirabayashi, N., Sato, N.S. and Suzuki, T. Conserved loop sequence of helix 69 in Escherichia coli 23S rRNA is involved in the A-site tRNA binding and translational fidelity
    J. Biol. Chem, 281, 17203-17211 (2006) [Pubmed]
  • Noma, A., Kirino, Y., Ikeuchi, Y. and Suzuki, T. Biosynthesis of wybutosine, a hyper-modified nucleoside in eukaryotic phenylalanine tRNA
    EMBO J., 25, 2142-2154 (2006) [Pubmed]
  • Kirino, Y., Yasukawa, T., Marjavaara, S.K., Jacobs, H.T., Holt, I.J., Watanabe, K. and Suzuki, T. Acquisition of the wobble modification in mitochondrial tRNALeu(CUN) bearing the G12300A mutation suppresses the MELAS molecular defect
    Hum Mol Genet., 15, 897-904 (2006) [Pubmed]
  • Takano, Y., Takayanagi, N., Hori, H., Ikeuchi, Y., Suzuki, T., Kimura, A. and Okuno, T. A gene involved in modification of transfer RNA is required for fungal pathogenicity and stress tolerance of Colletotrichum lagenarium.
    Mol Microbiol., 60, 81-92 (2006) [Pubmed]
  • Shigi, N., Sakaguchi, Y., Suzuki, T. and Watanabe, K. Identification of two tRNA-thiolation genes required for cell growth at extremely high temperatures
    J. Biol. Chem., 281, 14296-14306 (2006) [Pubmed]
  • Shigi, N., Suzuki, T., Terada, T., Shirouzu, M., Yokoyama, S. and Watanabe, K. Temperature-dependent biosynthesis of 2-thioribothymidine of Thermus thermophilus tRNA
    J. Biol. Chem., 281, 2104-2113 (2006) [Pubmed]
  • Numata, T., Fukai, S., Ikeuchi, Y., Suzuki, T. and Nureki, O. Structural basis for sulfur relay to RNA mediated by heterohexameric TusBCD complex
    Structure, 14, 357-366 (2006) [Pubmed]
  • Ikeuchi, Y., Shigi, N. Kato, J., Nishimura, A. and Suzuki, T. Mechanistic insights into sulfur-relay by multiple sulfur mediators involved in thiouridine biosynthesis at tRNA wobble positions
    Mol Cell., 21, 97-108 (2006) [Pubmed]

Symposium series

  • Noma, A. and Suzuki, T.
    Ribonucleome analysis identified enzyme genes responsible for wybutosine synthesis
    Nucleic Acids Symp Ser (Oxf), 50, 65-66 (2006)
  • Kitahara, K., Sato, N. S., Namba, N., Yokota, T., Tsujimura, T. and Suzuki, T.
    Systematic deletion of rRNAs for investigating ribosome architecture and function
    Nucleic Acids Symp Ser (Oxf), 50, 287-288 (2006)
  • Kirino, Y., Yasukawa, T., Suzuki, T., Suzuki, T. and Watanabe, K.
    Molecular mechanism of MELAS caused by Taurine-modification defect in mitochondrial tRNA
    Third International Congress on Vascular Dementia, p69-73 (2003)
  • Katoh, T., Susa, M., Suzuki, T., Umeda, N., Watanabe, K. and Suzuki, T.
    Simple and rapid synthesis of siRNA derived from in vitro transcribed shRNA.
    Nucleic Acids Research Supplement, 3, 249-250 (2003)
  • Kurata, S., Ohtsuki, T., Wada, T., Kirino, Y., Takai, K., Saigo, K., Watanabe, K. and Suzuki, T.
    Decoding property of C5 uridine modification at the wobble position of tRNA anticodon.
    Nucleic Acids Research Supplement, 3, 245-246 (2003)
  • Zhang, L., Sato, N. S., Watanabe, K. and Suzuki, T.
    Functional genetic selection of the decoding center in E. coli 16S rRNA.
    Nucleic Acids Research Supplement, 3, 319-320 (2003)
  • Tomari, Y., Suzuki, T. and Ueda, T.
    tRNA Recognition by CCA-adding enzyme.
    Nucleic Acids Research Supplement, 2, 77-78 (2002)
  • Shimada, N., Matsuzaki, R., Suzuki, T., Suzuki, T. and Watanabe, K.
    Quality control of translation through the kinetic discrimination of tRNAs in the network of aminoacyl-tRNA synthetases.
    Nucleic Acids Research Supplement, 2, 79-80 (2002)
  • Wada T., Shimazaki T., Nakagawa S., Otuki T., Kurata S., Suzuki .T, Watanabe K., Saigo K.
    Chemical synthesis of novel taurine-containing uridine derivatives.
    Nucleic Acids Research Supplement, 2, 11-12 (2002)
  • Suzuki, T., Suzuki, T., Wada, T., Saigo, K. and Watanabe, K.
    Novel Taurine-Containing Uridine Derivatives and mitochondrial human disease.
    Nucleic Acids Research Supplement, 1, 257-258 (2001)
  • Hanada, T., Suzuki, T. and Watanabe, K.
    Translation activity of mitochondrial tRNA with unusual secondary structure.
    Nucleic Acids Symposium Series., 44, 249-250 (2000)
  • Hori, H., Suzuki, T., Sugawara, K., Inoue, Y., Shibata, T., Kuramitsu, S.,Yokoyama, S., Oshima, T. and Watanabe, K. Identification of Thermus thermophilus HB8 tRNA (Gm18) methyltransferase gene.
    Nucleic Acids Symposium Series., 44, 167-168 (2000)
  • Yasukawa, T., Suzuki, T., Ueda, T., Hayashi, J., Ohta, S. and Watanabe, K.
    Stability of mitochondrial tRNA molecules with pathogenic point mutations.
    Nucleic Acids Symposium Series., 39, 257-258 (1998)
  • Ueda, T., Suzuki, T. and Watanabe, K. Polysemous codon.
    Nucleic Acids Symposium Series., 35, 213-214 (1996)

著書

  • 「転写後修飾によるRNA機能制御」櫻井雅之、鈴木 勉 細胞工学(2月号)(秀潤社)(2009)
  • 「大腸菌からのRNA抽出」宮内健常、鈴木 勉 RNA実験ノート上(RNAの基本的な取り扱いから解析手法まで)(羊土社)p17-20 (2008)
  • 「質量分析法を用いたRNA修飾ヌクレオシドの解析」鈴木健夫、鈴木 勉 RNA実験ノート上(RNAの基本的な取り扱いから解析手法まで)(羊土社)p177-181 (2008)
  • 「有効なsiRNAのデザインと細胞への導入」加藤敬行、鈴木 勉 RNA実験ノート下(小分子RNAの解析からRNAiへの応用まで)(羊土社)p99-102 (2008)
  • 「RNAとゲノム(最近の話題)」-座談会 機能性RNA研究の展望- 渡辺公綱、浅井 潔、鈴木 勉、廣瀬哲郎 ゲノム医学 Vol.7(No.2) p79-84 (2007)
  • 「マススペクトロメトリーによるncRNAの解析」鈴木 勉、鈴木健夫、上田宏生、宮内健常、坂口裕理子 RNAと生命(蛋白質核酸酵素12月号増刊)(共立出版)(2006)
  • 「RNA修飾酵素の細胞内局在とRNA成熟化機構」野間章子、鈴木 勉 細胞核の世界(蛋白質核酸酵素11月号増刊)(共立出版)(2006)
  • 「RNA修飾酵素の網羅的探索と機能・構造解析」池内与志穂、鈴木 勉 タンパク3000プロジェクト個別的解析プログラム「転写・翻訳」ニュースレター No. 6, (2006)
  • 「RNAマススペクトロメトリー」鈴木 勉、鈴木健夫、坂口裕理子 メディカルレヴュー社 (2006)
  • 「遺伝暗号の変遷と進化的普遍性」渡辺公綱、鈴木 勉 蛋白質 核酸 酵素(共立出版)(2006)
  • 「RNA修飾に関わる硫黄リレータンパク質群の同定」池内与志穂、鈴木 勉 細胞工学(4月号)(秀潤社)(2006)
  • 「RNA修飾の世界―見過ごされているRNAの質的な情報」鈴木 勉 生化学会誌12月号(2005)
  • 「リボソームの立体構造と抗生物質の作用機所」北原 圭、鈴木 勉 RNA工学の最前線(監修 中村義一)シーエムシー出版 (2005)
  • 実験医学特集「解明が進むRNAの成熟化プロセス」(監修 鈴木 勉、廣瀬哲郎)「機能性RNA研究におけるRNAプロセシングの重要性」鈴木 勉、廣瀬哲郎 実験医学(7月号)(羊土社)(2005)
  • 実験医学特集「解明が進むRNAの成熟化プロセス」(監修 鈴木 勉、廣瀬哲郎)「RNA修飾の生合成と機能」鈴木 勉 実験医学(7月号)(羊土社)(2005)
  • 「aaRS-tRNAネットワークと翻訳精度維持機構」長尾翌手可、鈴木 勉 タンパク3000プロジェクト個別的解析プログラム「転写・翻訳」ニュースレター No. 5, (2005)
  • 「哺乳動物ミトコンドリアの翻訳系―ミトコンドリアゲノムの縮小によってもたらされたユニークなシステム」鴫 成実、鈴木 勉、蛋白質 核酸 酵素(共立出版)(3月増刊号)「二層膜オルガネラの遺伝学」 (2005)
  • 「MELASにおけるA3243G変異とtRNA修飾異常」桐野陽平、鈴木 勉「臨床検査」医学書院(2005)
  • 「RNAiにおけるsiRNAの合理的配列設計法」鈴木 勉、加藤敬行「RNAi法とアンチセンス法―RNAの科学と応用」講談社サイエンティフィク(2005)
  • 「RNA干渉による新しい遺伝子発現制御技術と創薬」鈴木 勉 テクノニュースちば(2005)
  • 「機能性RNAのマススペクトロメトリー」鈴木 勉、池内与志穂、鈴木健夫「躍進するRNA研究」実験医学11月増刊号(2004)
  • 「in vitro転写による新規siRNA合成法とRNAi活性予測アルゴリズムの開発」鈴木 勉、加藤敬行 「改訂RNAi実験プロトコール」、195-207(2004)
  • 「新規転写合成法を用いたsiRNAの高効率調製法」鈴木 勉、加藤敬行「RNA工学の医学への展開」(最新医学社)(2004)
  • 「siRNA予測アルゴリズムの開発」加藤敬行、鈴木 勉「RNA工学の医学への展開」(最新医学社)(2004)
  • 「リボヌクレオームとの融合-RNAの機能異常と疾患」鈴木 勉、渡辺公綱 「疾患プロテオミクスの最前線」(メディカルドゥ)(2004)
  • 「ミトコンドリア翻訳関連因子の構造解析」鈴木 勉 タンパク3000プロジェクト個別的解析プログラム「転写・翻訳」ニュースレター No. 3, (2004)
  • 「ミトコンドリアtRNAのタウリン修飾と疾患」鈴木 勉、医学のあゆみ(医歯薬出版)(2004)
  • 「変異tRNAの修飾欠損とミトコンドリア病の発症機構」鈴木 勉、Molecular Medicine (中山書店) Vol.41 (No.3) (2004)
  • 「新規転写合成siRNAとRNAi活性予測アルゴリズムの開発」鈴木 勉、バイオインダストリー(シーエムシー)Vol. 21, No. 1(1月号), 25-35 (2004)
  • 細胞工学特集「リボヌクレオーム:機能性RNAが活躍する転写後の世界」(監修 鈴木 勉)「序論 リボヌクレオーム:広がる転写後プロセシングの世界」鈴木 勉、細胞工学(9月号)(秀潤社) Vol. 22 (No.9), 936-938 (2003)
  • 「リボヌクレオーム解析:RNA修飾遺伝子の網羅的探索」池内与志穂、鈴木 勉、細胞工学(9月号)(秀潤社) Vol. 22 (No.9), 945-950 (2003)
  • 「RNA修飾異常と疾患」鈴木 勉、桐野陽平、渡辺公綱、細胞工学(9月号)(秀潤社) Vol. 22 (No.9), 969-973 (2003)
  • 「遺伝子の多型が個性を作る」鈴木 勉、化学と教育(日本化学会)、51巻7号、p402-405(2003)
  • 「ミトコンドリア翻訳関連因子の構造解析」鈴木 勉 タンパク3000プロジェクト個別的解析プログラム「転写・翻訳」ニュースレター No. 1, 51-53 (2003)
  • 「SSER法の開発とリボソーム研究への応用」鈴木 勉 RNA Network Newsletter Vol. 2 (No.1) 94-96 (2003)
  • 「第6章 リボソーム(ribosome is ribozyme)」鈴木 勉 わかる実験医学シリーズ「RNAがわかる」(羊土社)p130-136
  • 「第3章 翻訳」渡辺公綱、鈴木 勉、姫野俵太 「分子生物学イラストレイテッド(第2版)」(羊土社)、56-64 (2003)
  • 「2002年度ノーベル化学賞」 鈴木 勉 からだの科学2月号(239号) (日本評論社)(2003)
  • 「ミトコンドリアの翻訳システム」渡辺公綱、大槻高史、鈴木 勉 蛋白質 核酸 酵素(共立出版), (3月増刊号)「RNAの細胞生物学」48, 365-374 (2003).
  • 「リボソームRNA(rRNA)の生合成とリボソームの構造」鈴木 勉、渡辺公綱 日本臨床 日本臨床増刊「ミトコンドリアとミトコンドリア病」(日本臨床社)41-45 (2002)
  • 「変異ミトコンドリアtRNAの修飾欠損とdecoding異常」安川武宏、鈴木 勉、太田茂男、渡辺公綱 日本臨床増刊「ミトコンドリアとミトコンドリア病」(日本臨床社)197-201 (2002)
  • 「リボヌクレオーム解析」鈴木 勉、渡辺公綱 現代化学増刊42「プロテオミクス―方法とその病態解析への応用―」(東京化学同人) 65-69 (2002)
  • 「リボソーム研究の新しい潮流―リボソームミーティングに参加して―」鈴木 勉 RNA Network Newsletter Vol. 1 (No.1) 18-19 (2002)
  • 「リボソームはリボザイムであった―X線結晶構造解析が解き明かすペプチド転移反応のメカニズム―」 鈴木 勉、渡辺公綱、蛋白質 核酸 酵素(共立出版), 46, 1268- (2001)
  • 「リボソームの構造機能研究の最先端―X線結晶構造解析が解き明かしたリボソームの機能―」鈴木 勉、渡辺公綱 蛋白質 核酸 酵素, (8月増刊号)「新世紀における蛋白質科学の進展」(共立出版)46, 1635-1644 (2001)
  • 「第4章 ミトコンドリアtRNAの特異構造と翻訳特性」 渡辺公綱、鈴木 勉 「RNA研究の最前線」(シュプリンガー・フェアラーク東京株式会社)(2000)
  • タンパク質の誕生~遺伝情報の翻訳の謎」渡辺公綱、鈴木 勉 「バイオサイエンスの新世紀」第2巻タンパク質の一生(日本生化学会編集)(2000)
  • 「生命の起源-RNAワールド仮説」 渡辺公綱、鈴木 勉 「遺伝」別刷 No. 12 地球の進化・生命の進化(裳華房)(2000)
  • 「核酸の検出と定量」 鈴木 勉 「基礎生化学実験法」、第4巻 核酸・遺伝子実験(基礎編)(東京化学同人) (2000)
  • 「リボヌクレオームの世界-RNA転写後修飾の機能-」 鈴木 勉、渡辺公綱、バイオインダストリー(シーエムシー)Vol. 17, No. 11(2000)
  • 「ミトコンドリアへのRNAの輸送:メカニズムの解明と医学生物学的意義」鈴木 勉 Newsletter Research on HFSP in Japan, No. 13 (1999)
  • 「多義語コドンの発見-複数のアミノ酸と結合するファジーなtRNA-」上田卓也,鈴木 勉,渡辺公綱, 蛋白質 核酸 酵素(共立出版), 42, 1815-1827 (1997)

Publication (* corresponding author)

2005

  • Ote, T., Hashimoto, M., Ikeuchi, Y., Suetsugu, M., Suzuki, T., Katayama, T. and Kato, J. Involvement of the Escherichia coli folate-binding protein YgfZ in RNA modification and regulation of chromosomal replication initiation
    Mol Microbiol., 59, 265-275 (2005)
  • Zhang, L., Ching Ging, N., Komoda, T., Hanada, T., Suzuki, T.* and Watanabe, K. Antibiotic susceptibility of mammalian mitochondrial translation
    FEBS Lett., 579, 6423-6427 (2005)
  • Ikeuchi, Y., Soma, A., Ote, T., Kato, J., Sekine, Y. and Suzuki, T.* Molecular mechanism of lysidine synthesis that determines tRNA identity and codon recognition
    Mol Cell., 19, 235-246 (2005)
  • Chimnaronk, S., Jeppesen, M.G., Suzuki, T., Nyborg, J. and Watanabe, K. Dual Mode Recognition of Noncanonical tRNAsSer by Seryl-tRNA Synthetase in Mammalian Mitochondria
    EMBO J., 24, 3369-3379 (2005)
  • Kirino, Y., Goto, Y., Campos, Y., Arenas, J. and Suzuki, T.* Specific correlation between tRNA taurine-modification deficiency and clinical features of human mitochondrial disease
    Proc. Natl. Acad. Sci. USA., 102, 7127-7132 (2005)
  • Nakanishi, K., Fukai, S., Ikeuchi, Y., Soma, A., Sekine, Y., Suzuki, T. and Nureki, O. Structural basis for lysidine formation by ATP pyrophosphatase accompanied with a lysine-specific loop and a tRNA-recognition domain
    Proc. Natl. Acad. Sci. USA., 102, 7487-7492 (2005)
  • Yasukawa, T., Kirino, Y., Ishii, N., Holt, I.J., Jacobs, H.T., Makifuchi, T., Fukuhara, N., Ohta, S., Suzuki, T.* and Watanabe, K. Wobble modification deficiency in mutant tRNAs in patients with mitochondrial diseases
    FEBS Lett., 579, 2948-2952 (2005)
  • Sakurai, M., Ohtsuki, T., Suzuki, T. and Watanabe, K. Unusual usage of wobble modification in mitochondrial tRNAs of the nematode Ascaris suum.
    FEBS Lett., 579, 2767-2772 (2005)
  • Nagaike, T., Suzuki, T.*, Katoh, T. and Ueda, T. Human mitochondrial mRNAs are stabilized with polyadenylation regulated by mitochondria-specific poly(A) polymerase and polynucleotide phosphorylase
    J. Biol. Chem., 280, 19721-19727 (2005)
  • Kirino, Y. and Suzuki, T.* Human Mitochondrial Diseases Associated with tRNA Wobble Modification Deficiency
    RNA biol., 2, 41-44 (2005)
  • Suzuki, T. Biosynthesis and function of tRNA wobble modifications. In Fine-tuning of RNA functions by modification and editing
    Topics in Current Genetics, vol 12, Springer-Verlag, NY pg 24-69 (2005)
  • Umeda, N., Suzuki, T., Yukawa, M., Ohya, Y., Shindo, H., Watanabe, K. and Suzuki, T.* Mitochondria-specific RNA-modifying enzymes responsible for the biosynthesis of the wobble base in mitochondrial tRNAs: Implications for the molecular pathogenesis of human mitochondrial diseases.
    J. Biol. Chem., 280, 1613-1624 (2005)

2004

  • Okamoto, H., Watanabe, K., Ikeuchi, Y., Suzuki, T., Endo, Y. and Hori, H. Substrate tRNA recognition mechanism of tRNA (m7G46) methyltransferase from Aquifex aeolicus
    J. Biol. Chem., 279, 49151-49159 (2004)
  • Kirino, Y., Yasukawa, T., Ohta, S., Akira, S., Ishihara, K., Watanabe, K. and Suzuki, T.* Codon-specific translational defect caused by a wobble modification deficiency in mutant tRNA from a human mitochondrial disease
    Proc. Natl. Acad. Sci. USA., 101, 15070-15075 (2004)
  • Sato, N. S., Suzuki, T., Ueda, T., Watanabe, K., Hirata, R. D. and Hirata, M. H. Recombinant antigen-based immuno-slot blot method for serodiagnosis of syphilis.
    Braz J Med Biol Res., 37(7), 949-955 (2004)
  • Chimnaronk, S., Jeppesenb, M.G., Shimada, N., Suzuki, T., Nyborg, J. and Watanabe, K. Crystallization and preliminary X-ray diffraction study of mammalian mitochondrial Seryl-tRNA synthetase.
    Acta Crystallographica Section D, 60, 1319-1322 (2004)
  • Nakai, Y., Umeda, N., Suzuki, T., Nakai, M., Hayashi, H., Watanabe, K. and Kagamiyama, H. Yeast Nfs1p is involved in thio-modification of both mitochondrial and cytoplasmic tRNAs.
    J. Biol. Chem., 279, 12363-12368 (2004)
  • Hino, N., Suzuki, T., Yasukawa, T., Seio, K., Watanabe, K. and Ueda, T. The pathogenic A4269G mutation in human mitochondrial tRNAIle alters the T-stem structure and decreases the binding affinity of elongation factor Tu
    Genes Cells, 9, 243-252 (2004)
  • Terasaki, M., Suzuki, T.*, Hanada, T. and Watanabe, K. Functional compatibility of elongation factors between mammalian mitochondrial and bacterial ribosomes: Characterization of GTPase activity and translation elongation by hybrid ribosomes bearing heterologous L7/12 proteins
    J. Mol. Biol., 336, 331-342 (2004)
  • Limongelli, A., Schaefer J., Jackson, S., Invernizzi, F., Kirino, Y., Suzuki, T., Reichmann, H. and Zeviani, M. Variable penetrance of a familial progressive necrotizing encephalopathy due to a novel tRNAIle homoplasmic mutation in the mitochondrial genome
    J Med Genet, 41, 342-349 (2004)
  • Suzuki, T., Ohtsuki, T. and Watanabe, K. Glimpses of transitions from the RNA world to the RNP world in protein compensation for RNA deficit in animal mitochondrial translation systems.
    Endocytobiosis Cell Res, 15, 110-122 (2004)

2003

  • Kurata, S., Ohtsuki, T., Suzuki, T. and Watanabe, K. Quick two-step RNA ligation employing periodate oxidation.
    Nucleic Acids Res., 31, e145 (2003)
  • Soma, A., Ikeuchi, Y., Kanemasa, S., Kobayashi, K., Ogasawara, N., Ote, T., Kato, J., Watanabe, K., Sekine, Y. and Suzuki, T.* An RNA-modifying enzyme that governs both the codon and amino acid specificities of isoleucine tRNA.
    Mol Cell, 12, 689-698 (2003)
  • Ying, B., Suzuki, T., Shimizu, Y. and Ueda, T. A novel screening system for self-mRNA targeting proteins.
    J. Biochem., 133, 485-491 (2003)
  • Tomari, Y., Hino, N., Nagaike, T., and Suzuki, T.* and Ueda, T. Decreased CCA-addition of human mitochondrial tRNAs bearing pathogenic A4317G or A10044G mutation.
    J. Biol. Chem., 278, 16828-16833 (2003)
  • Kamiya, N., Tanaka, T., Suzuki, T., Takezawa, T., Takeda, S., Watanabe, K. and Nagamune, T. S-peptide as a potent peptidyl linker for protein crosslinking by microbial transglutaminase from Streptomyces mobaraensis.
    Bioconjugate Chemistry 14, 351-357 (2003)
  • Kaneko, T., Suzuki, T., Kapushoc, S.T., Rubio, M.A., Ghazvini, J., Watanabe, K., Simpson, L. and Suzuki, T.* Wobble modification differences and subcellular localization of tRNAs in Leishmania tarentolae: implication for tRNA sorting mechanism.
    EMBO J., 22, 657-667 (2003)

2002

  • Suzuki, T., Suzuki, T.*, Wada, T., Saigo K. and Watanabe, K. Taurine as a constituent of mitochondrial tRNAs: New insights into the functions of taurine and human mitochondrial diseases.
    EMBO J., 21, 6581-6589 (2002)
  • Shigi, N., Suzuki, T., Tamakoshi, M., Oshima, T. and Watanabe, K. The conserved bases in TYC loop of tRNA are determinants for Thermophile-specific 2-thiolation of U54.
    J. Biol. Chem., 277, 39128-39135 (2002)
  • Cho, H. D., Tomita, K., Suzuki, T. and Weiner, A. M. U2 snRNA is a substrate for the CCA-adding enzyme (tRNA nucleotidyltransferase)
    J. Biol. Chem., 277, 3447-3455 (2002)
  • Toompuu, M., Yasukawa, T., Suzuki, T., Hakkinen, T., Spelbrink, J.N., Watanabe, K. and Jacobs, H.T. The 7472insC mitochondrial DNA mutation impairs the synthesis and extent of aminoacylation of tRNASer(UCN) but not its structure or rate of turnover.
    J. Biol. Chem., 277, 22240-22250 (2002)
  • Yasukawa, T., Suzuki, T., Ohta, S. and Watanabe, K. Wobble modification defect suppresses translational activity of tRNAs with MELAS an MERRF mutations.
    Mitochondrion, 2, 129-141 (2002)
  • Suzuki, T., Ohtsuki, T., Watanabe, Y., Terasaki, M., Hanada, T. and Watanabe, K. Structural and functional compensation by proteins for the RNA deficit of animal mitochondrial translation systems.
    Cell-Free Translation Systems, Chapter 17, p183-196 (Eds. Spirin, A. et al., Springer) (2002)
  • Hori, H., Suzuki, T., Sugawara, K., Inoue, Y., Shibata, T., Kuramitsu, S., Yokoyama, S., Oshima, T. and Watanabe, K. Identification and Characterization of Thermus thermophilus HB8 tRNA-(Gm18)-methyltransferase; Domain Structure and Conserved Amino Acid Sequence Motifs in the Enzyme.
    Genes Cells, 7, 259-272 (2002)

2001

  • Yasukawa, T., Suzuki, T., Ishii, N., Ohta, S. and Watanabe, K. Wobble modification defect in tRNA disturbs codon-anticodon interaction in a mitochondrial disease.
    EMBO J., 20, 4794-4802 (2001)
  • Suzuki, T.*, Terasaki, M., Takemoto-Hori, C., Hanada, T., Ueda, T., Wada, A. and Watanabe, K. Structural compensation for deficit of rRNA with proteins in mammalian mitochondrial ribosome; systematic analysis of protein components of the large ribosomal subunit from mammalian mitochondria.
    J. Biol. Chem., 276, 21724-21736 (2001)
  • Suzuki, T.*, Terasaki, M., Takemoto-Hori, C., Hanada, T., Ueda, T., Wada, A. and Watanabe, K. Proteomic Analysis of the Mammalian Mitochondrial Ribosome; Identification of protein components in the 28S Small Subunit.
    J. Biol. Chem., 276, 33181-33195 (2001)
  • Nagaike, T., Suzuki, T.*, Tomari, Y., Takemoto-Hori, C., Negayama, F., Watanabe, K. and Ueda, T. Identification and Characterization of Mammalian Mitochondrial tRNA-Nucleotidyltransferases.
    J. Biol. Chem., 276, 40041-40049 (2001)
  • Shimada, N., Suzuki, T. and Watanabe, K. Dual mode recognition of two isoacceptor tRNAs by mammalian mitochondrial seryl-tRNA synthetase.
    J. Biol. Chem., 276, 46770-46778 (2001)
  • Yokobori, S, Suzuki, T. and Watanabe, K. Genetic code variations in mitochondria: tRNA as a major determinant of genetic code plasticity.
    J. Mol. Evol., 53, 314-326 (2001)
  • Kenmochi, N., Suzuki, T., Uechi, T., Magoori, M., Kuniba, M., Higa, S., Watanabe, K. and Tanaka, T. The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders.
    Genomics, 77, 65-70 (2001)
  • Hanada, T., Suzuki, T., Yokogawa, T., Takemoto-Hori, C., Sprinzl, M. and Watanabe, K. Translation ability of mitochondrial tRNAsSer with unusual secondary structures in an in vitro translation system of bovine mitochondria.
    Genes Cells, 6, 1019-1030 (2001)
  • Shimizu, Y., Inoue, A., Tomari, Y., Suzuki, T., Yokogawa, T., Nishikawa, K. and Ueda, T. Cell-free translation reconstituted with purified components.
    Nature Biotechnology, 19, 751-755 (2001)

2000

  • Yasukawa, T., Suzuki, T., Suzuki, T., Ueda, T., Ohta, S. and Watanabe, K. Modification Defect at Anticodon Wobble Nucleotide of Mitochondrial tRNAsLeu(UUR) with Pathogenic Mutations of Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, and Stroke-like Episodes.
    J. Biol. Chem., 275, 4251-4257 (2000)
  • Yasukawa, T., Suzuki, T., Ishii, N., Ueda, T., Ohta, S. and Watanabe, K. Defect in Modification at the Anticodon Wobble Nucleotide of Mitochondrial tRNALys with the MERRF Encephalomyopathy Pathogenic Mutation.
    FEBS Lett., 467, 175-178 (2000)
  • Tin, O. F., Rykunova, A. I., Muranova, T. A., Toyoda, T., Ito, K., Suzuki, T., Watanabe, K., Garber, M. B. and Nakamura, Y. Proteolytic fragmentation of polypeptide release factor 1 of Thermus thermophilus and crystallization of the stable fragments.
    Biochimie, 82, 765-772 (2000)
  • Yokogawa, T., Shimada, N., Takeuchi, N., Benkowski, L., Suzuki, T., Omori, A., Ueda, T., Nishikawa, K., Spremulli, L. and Watanabe K. Characterization and tRNA recognition of mammalian mitochondrial Seryl tRNA synthetase.
    J. Biol. Chem., 275, 19913-19920 (2000)
  • Tomari, Y., Suzuki, T.*, K Watanabe, K. and Ueda, T. Role of tightly bound ATP in Escherichia coli tRNA nucleotidyltransferase.
    Genes Cells, 5, 689-698 (2000)
  • Yasukawa, T., Hino, N., Suzuki, T., Watanabe, K., Ueda, T. and Ohta, S. A pathogenic point mutation reduces stability of mitochondrial mutant tRNAIle.
    Nucleic Acids Res., 28, 3779-3784 (2000)
  • Watanabe, K. and Suzuki, T. Genetic code and its Variants.
    the Encyclopedia of Life Science, (Macmillan Publishers Ltd) (2000)
  • Sato, N. S., Suzuki, T., Hirata M. H., Hirata, R. D. C., Ueda, T., Watanabe, K., Zerbini, L. C. M. S., Silveira, E. P. R., Melo, C. S. and Ueda, M. Novel immunoblot treponemal assay using recombinant antigens for immunodiagnosis of syphilis.
    Journal Brasileiro de Patologia, 36, 161-165 (2000)

-1999

  • Kondow, A., Suzuki, T., Yokobori, S., Ueda, T. and Watanabe, K. An extra tRNAGly(U*CU) found in ascidian mitochondria responsible for decoding non-universal codons AGA/AGG as glycine.
    Nucleic Acids Res., 27, 2554-2559 (1999)
  • Suzuki, T., Suzuki, T., Ueda, T. and Watanabe, K. High sensitive analysis of modified nucleosides by LC/MS using ESI / iontrap mass spectrometry.
    J. Mass Spectrom. Soc. Jpn., 47, 168-176 (1999)
  • Suzuki, T., Ueda, T. and Watanabe, K. The 'polysemous' codon - a codon with multiple amino acid assignment caused by dual specificity of tRNA identity.
    EMBO J., 16, 1122-1134 (1997)
  • Suzuki, T., Ueda, T. and Watanabe, K. A new method for identifying the amino acid attached to a particular RNA in the cell.
    FEBS Lett., 381, 195-198 (1996)
  • Suzuki, T., Ueda, T., Yokogawa, T., Nishikawa, K. and Watanabe, K. Characterization of serine and leucine tRNAs in an asporogenic yeast Candida cylindracea and evolutionary implication of genes for tRNASerCAG responsible for translation of a non-universal genetic code.
    Nucleic Acids Res., 22, 115-123 (1994)
  • Ueda, T., Suzuki, T., Yokogawa, T., Nishikawa, K. and Watanabe, K. Unique structure of new serine tRNAs responsible for decoding leucine codon CUG in various Candida species and their putative ancestral tRNA genes.
    Biochimie, 76, 1217-1222 (1994)
  • Suzuki, T., Ueda, T., Ohama, T., Osawa, S. and Watanabe, K. The gene serine tRNA having anticodon sequence CAG in a pathogenic yeast, C. albicans.
    Nucleic Acids Res., 21, 356 (1993)
  • Watanabe, K., Ueda, T., Yokogawa, T., Suzuki, T., Nishikawa, K., Mori, M., Ohama, T., Nakabayashi, H., Nakase, T. and Osawa, S. Molecular mechanism of the genetic code variations found in Candida species and its implications in evolution of the genetic code.
    The Translational Apparatus Structure, Function, Regulation, Evolution (Nierhaus, K. H. et al. eds), Plenum, New York, pp647-656 (1993)
  • Ohama, T., Suzuki, T., Mori, M., Osawa, S., Ueda, T., Watanabe, K. and Nakase, T. Non-universal decoding of the leucine codon CUG in several Candida species.
    Nucleic Acids Res., 21, 4039-4045 (1993)
  • Yokogawa, T., Suzuki, T., Ueda, T., Mori, M., Ohama, T., Kuchino, Y., Yoshinari, S., Motoki, I., Nishikawa, K., Osawa, S. and Watanabe, K. Serine tRNA complementary to the nonuniversal serine codon in Candida cylindracea : Evolutionary implications.
    Proc.Natl. Acad. Sci. USA., 89, 7408-7411 (1992)
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